![]() a multiprotein complex involved in the translocation of nascent polypeptides, and in this case, from the cytosol to the interior of the rER across the rER membranes. A cue is a particular protein-nucleic acid complex that forms in the cytosol. They bind to it when it starts to synthesize membrane-bound proteins destined for sorting. Nevertheless, the ribosomes that give the endoplasmic reticulum a ‘rough’ appearance are not always bound to the ER. The organelle synthesizes and secretes serum proteins (such as albumin) in the liver, and hormones (such as insulin) and other substances (such as milk) in the glands. ![]() The presence of ribosomes on rER is an indication that the latter is involved in protein synthesis and secretion. ![]() The rER is bears many ribosomes on its outer surface giving it a rough appearance as seen under the microscope hence, the name. ![]()
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